This is my first mobafire build post and I am pretty straight to the point, Vayne is an amazing hero she can shred tanks like crazy I have a lot of high scoring games using these 2 builds so I hope everyone likes them.

Pros:
Vayne is a very strong DPS Hero
Moves quickly without much need for ghost
Her skills don't require a ton of mana so runes can easily keep you going all game, just having mana regen runes lets you harass with your tumble early as well.
You can build attack speed with a touch of damage and still annihilate your enemies
Can use tumble to dodge enemy attacks, catch up to someone, harass, well tumble is awesome

Cons:
If you can't keep your distance you will get blown up fast

Passive:
Night Hunter
Vayne ruthlessly hunts evil-doers. She gains bonus Movement Speed when moving toward nearby enemy champions.

Make you keep up with pretty much anyone with only a few exceptions her passive makes her a very good harasser and champion killer.

Tumble
Vayne tumbles, maneuvering to carefully place her next shot. She rolls toward the cursor and her next attack deals bonus damage.

Tumble has many uses, anything from dodging enemy attacks to getting that last killing blow in it is a very versatile skill.

Silver Bolts
Vayne tips her bolts with a rare metal, toxic to evil things. The third consecutive attack or ability against the same target deals a percentage of the target's maximum Health as bonus true damage. (Max damage vs. Monsters is capped)

This is what makes her a machine and is the reason that a lot of attack speed on her makes her so powerful, hitting true damage + more true damage based on their life every 3 hits is just amazing against the whole field and makes it so no tank is able to stand your damage for very long.

Condemn
Vayne draws a heavy crossbow from her back, and fires a huge bolt at her target, dealing damage and knocking them back. If they collide with terrain, they are impaled, dealing bonus damage and stunning them.

Gives her a way to deal some quick damage to opponent by sticking them against a wall, can also be used to knock an opponent back and give her a chance to escape.

Final Hour
Readying herself for an epic confrontation, Vayne gains increased Attack Damage, stealth during Tumble, and quadruple the bonus Movement Speed from Night Hunter.

The icing on the cake, gives her extra damage so she can build into speed mainly, gives stealth to her tumble which gives her enough time to emerge from a bush and surprise someone, or just to get away from someone, and if you are chasing someone down it makes you passive 4x better so they have no chance of getting away.

The only time I change up this build is when my opponent's are very squishy instead of building the madreds right away I would instead goto ainstead since it shreds squishies like nothing and can be sold later on to build better items, this item is insane for her as well as blood razer.

If you are having issues with getting stunned or locked down right away in a battle acan get you a bit more time to make your opponent dead.

I hope that this guide helps anyone who reads it, if not the build is solid and works very well so enjoy everyone!