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-ARCHAIC KNOWLEDGE (this helps your ghouls dmg alot).
I noticed in my match history that ~ 35% of my dmg output was MAGIC DMG!! So instead of getting +1% attack speed, get +15% magic penetration.
Also, since your building manamune... u should play 21/9/0 with 3 defensive points in:
-'Strength of spirit'
Health regen
1% of 500 mana = 5.2 hp per 5
1% of 1.3k mana = +13 hp per 5 (i dont know about u, but i usually complet my manamune at around 1.3k mana, to make it worht while :P)
1% of 2k mana = +20 hp per 5
much better then 2% of your base hp regen -.- and you dont need mana regen when you have tear and the occasional blue buff
I would not use hp glyphs, ever. Maybe hp seal and mana regen glyphs...
So i cant vote as in...
-5L1V3R