Never tried MS ones. I think they would do fine, but I'm starting Boots+3 Pots and Take 3 AP Quints, Mana Regen Seals, AP/level Glyphs and MPen Reds so I have no need for Doran's.
My runes sounds about the same as CS. But doesn't that depend on opponent too? Against skillshot opponent ms-quints is great. =)
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Use AP quints on 90% of all AP casters. I'm pretty sure Brand should be using them.
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I mean, if someone has Skillshots just Boots the **** out of them... I mean, that's why I happen to rape all Karthuses and Cassios in my mid. Just Gragas, uoh, those barrels so fast >.>
Ryze also doesn't scale well with AP.
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Quints should definitely be MS, mana or MrP. Mana/lvl is not worth it in quints.
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