It really depends on the lane you're playing in. Let's take the classic example of Caitlyn + Taric. Taric stuns, Cait puts a trap underneath and secure a Q hit. Supports fit different caries. Long range can go for Janna because of the less likely need of a heal, which can increase your overall damage - e.g. Kog'Maw, Ezreal, Caitlyn. Soraka for spaming spells all day. Sona for awesomeness in general - and high burst AD's :P
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