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One of the problems I have is your mana glyphs and flat mana regen seals. You will have some great mana regen early game but then after that, it kinda goes to the pooper. You constantly have to wait for enough mana to launch your R I have found when trying your build a few weeks ago. Also, without my usual CDR glyphs, it feels like I'm giving too much time for the enemy to guess where my next living artillery is going to land. I usually like ulting on them twice in a short amount of time.
Great overall start! I'm eagerly awaiting updates!
Malady and Wit's End are like made for eachother!
And the dorans blade, rather grab ring. if you go mid atleast. you can harass better.
and about maxing bio-arcan barrage first. yes it is your best skill but it is weak early game. at lvl 9 people has 1k hp ca. meaning wow 60 dmg pr strike. good but not epic. if you have it at rank 3 at lvl 9 you still deal 40 extra.
and maxing void ooze if going mid is best for out laning(and farming of you got the mana)
And i am also suprised about the items. they have very little aspeed, it looks like this build as most other focuses on bio-arcane barrage. and then hextech is kinda useless.
Switch hextech with rabadons or nashors(i saw you had it in the optional items)
rabadons will increase bio-arcan by alooot.
And the flash description is a little wrong. kog is not very gankable. easy to scout bushes with ulti and has a slow. so i say meh. not unless amumu and ww ganks you at same time from both sides.
and really? berserker greaves?
Those are the badest boots in game atm. what about sorcere's shoes? those will increase your dmg more than berserker. and better harassing early game.
And im suprised you did not include rylai's or frozen mallet. since you are auto attacker frozen helps and you spam skills(rylais) and you have no cd(why nashors should be in the primary build)
Dont take me wrong it is a very good build. but these are the things i think are dumb :)
and no i wont downvote but i wont upvote either.
Try these things and tell me what you think.