"Blizzard spoke thus; Thou shalt not BM. And the players replied Nay, I shall Play my hand with Lethal already on the board. And so Blizzard sent unto them this Brawl of Yogg, As a lesson for their sins of Pride and Greed, for he is the Prophet of Madness and RNG. On that day, the tavern descended into an era of chaos and darkness, until the weekend passed and everyone forgot all about it. Amen. Book of SMOrc, Verse 20, Chapter 4." - Feam T
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AD quints WILL deal more damage than CrD until you've built your first BIG crit item and that's when runes are most important. That's why you SHOULD use AD quints.
Marks are best as ArP or AD. Get what you like the most.