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I completely agree that Morello's Evil Tome should replace Nashor's Tooth and I'm glad to see you're doing it. However, your Quints and Marks aren't great choices. CDR (Cooldown Reduction) caps at 40%. With your build:
20% (Morello's) + 15% (Full Mejai) + 9% (Masteries) + 1.44% (Marks) + 5.85% (Glyphs) + 7.02% (Quints) = 58.31% = 18.31% extra CDR that does nothing.
Now, let's say you replaced the Marks and Quints for something a little more useful, like Magic Pen Marks and Flat Health Quints.
58.31% - 7.02% - 1.44% = 49.85% = 9.85% extra CDR
Now, we need to realize that Mejai stacks are hard to keep up, considering any decent team will focus the one with the Mejai to ruin their stacks. So, here's your CDR without Mejai.
49.85% - 15% = 34.85%
The game rounds this up to 35%. Now, here are the time difference between 35% vs. 40%, respectively.
Sear - 3.9 Sec vs. 3.6 Sec - .3 Sec
Pillar - 6.5 Sec vs. 6 Sec - .5 Sec
Conflag - 6.5 Sec vs. 6 Sec - .5 Sec
Pyro - 48.75 Sec vs. 45 Sec - 3.75 Sec
The only one this makes a minor difference in is his ultimate.
Other than that, the rest of your build is decent for a complete glass cannon, which is what I think you were going for here.
so like this ((Morello's Evil Tome)) except just using the square brackets.
You can also make pictures by using (icon=Morello's Evil Tome size=48) but again just using square brackets and choosing whatever size you would like.
As stated in the beginning I am adding an optional item route section. I will also emphasize Play Style section.
On a side note, how do I add in these pictures/icons?
Also on the topic of masteries, I forgot to mention that you should probably max out the movement speed as well and take the flash mastery.
The rest of teh guide is pretty good. Though I think going more in depth into laning/teamfighting.
I did enjoy the comboing section (I have something similar in my Swain guide if you want to check it out). Also adding some pictures/icons might help a bit.
I have nothing against a good defensive item, such as BV, but this build is strictly based on AP output, thus the use of Nashor's Tooth for the increased cooldown reduction and +55AP. If I were suggesting slightly more balanced Brand, then yes BV is valuable, but this is strictly for the damage. Does that answer your question?
EDIT:
How does the rest of the guide/build look?
Also in your masteries. Utility Mastery, Awareness, and Good Hands are all better than perseverence and expanded mind, I suggest you put max points in the former before filling out the latter.