I like Karthus more because if you stick him in mid he can still play a larger role in the game with his Ult by not even risking himself with death. Talon has to be fed up top I believe to be a huge threat to the game.
Talon if you wanna win everygame low elo and Karthus if you like to deal massive burst and then die and **** them all up with your ulti.
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