Alright, so I'll quickly sum this up.
Expunge is kinda at a 0.9:1 AP ratio, which is pretty damn good if you ask me! Since the ratio is so good, I guess there's a possibility that it could work out. However, as funny as AP Twitch would be, AD Twitch still reigns over AP due to that fact that you have to stack SIX stacks to maximize the damage of Expunge. Why not just go AD, and KILL them while stacking up Expunge? (; . Sounds like you're just doing more work instead of just facerolling! But again, AP can work, but AD is still better.
When it comes to Magic DMG and Physical Damage, I like to get a mix of both kinda. If you look at my Twitch guide *cough cough subliminal messaging*, you will see that I tend to get a
Madred's Bloodrazors, and that I mainly build Twitch AD. Twitch is a huge AD champion, and should be built that way, but the Madred's gives Twitch's auto attacks some deadly Magic DMG, AS and AD. So, my build forces tanks to build AP AND AD. And it also forces the carries/supports on the other team to scatter for whatever Magic Resist/Armor they can get!
Expunge is kinda at a 0.9:1 AP ratio, which is pretty damn good if you ask me! Since the ratio is so good, I guess there's a possibility that it could work out. However, as funny as AP Twitch would be, AD Twitch still reigns over AP due to that fact that you have to stack SIX stacks to maximize the damage of Expunge. Why not just go AD, and KILL them while stacking up Expunge? (; . Sounds like you're just doing more work instead of just facerolling! But again, AP can work, but AD is still better.
When it comes to Magic DMG and Physical Damage, I like to get a mix of both kinda. If you look at my Twitch guide *cough cough subliminal messaging*, you will see that I tend to get a

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the idea was to get malady/cleaver/rageblade/boots(probably sorcs) and then 2 other things, probably more ap or ad.
the point was that you have some good attack speed and damage, with anti armor and mr, hitting multiple targets with ad and poison, and then using expunge for its 1:1 ratio.
any thoughts?