This was a thing once. Riot decided that it should be a thing and that jungle Nunu should be a thing. They've given him every incentive to stay in the jungle and far away from lanes. They've since also nerfed the reason to even lane him, so please let it die. :p
Nunu is generally a support, so he can lane with anyone. But he does really well, as you should know, on champs which rely onto attack speed and movement speed, so maybe duo with Tryndamere and make Tryndamere a real nightmare. If you really want the 2-1-2 + jungle strategy, also both Tryndamere and Nunu can jungle.

Nunu top is still quite strong imo, he has sustain for dayz in both mana and HP to stay in his lane forever. Snowballs hurt a lot with very little AP. I think he still counters quite a few, especially AA-reliable champions such as
Jax (really , the attack speed slow hurts their damage). I think
Nunu & Willump is quite weak against sustained ranged champions. Late-game he falls kinda behind if his ulti gets wasted.
Mercury's,
Spirit Visage,
Rabadon's Deathcap,
Frozen Heart and
Abyssal Mask are some good items on him. I don't like it to go full offensive, since he just falls behind too much in late-game.
Masteries I'd say 9/21/0 instead.
Runepage seems good.


Mercury's,




Masteries I'd say 9/21/0 instead.
Runepage seems good.
ah, so that's how randomizing signatures works.
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As far as my
Runes
Item Sequence