Welcome to my 1st guide :) As the title suggests, This is all about KARMA! =D She is very underplayed and has one of the best early laning phases in the game. Unfortunately, Karma falls off late game so it's important to harness her early game power to win the match!

Karma gains her ultimate at level one. How you use your ultimate depends on the situation. If your 1v1'ing an enemy and your at medium health, Renewal is a good choice for the bonus damage and healing. If an opponent is at low health, say, 20%, Casting Soulflare will instantly kill them! In teamfights, Defiance is also a pretty good option too. Karma has 7 abilities technically so use them wisely! Your Q will reduce your ultimates cooldown by 2 seconds and your W by 6 seconds if it lasts the full duration! Your Soulflare is the highest damage mantra ability. However, Renewal deals more damage than Soulflare -ASSUMING- The cataclysm didn't hit them. Think in your head before you cast either one. If they will dodge the explosion effect, It's probably better to cast Renewal.

Pro's: Con's
*Can spam Q. *Easy to Play. Hard to Master.
*Passive allows you to use ultimate 2 or even 3 times in a fight. *Falls off Late Game.
*High burst. *Lacks damage without items.
*High Sustain. *Underplayed.
*Great 1v1 duelist. *Relies on Mantra.

Different Combo's are better in different situations.

Catching an Enemy up: E yourself, W, R, Q.
Letting an Ally get in reach of an enemy: E ally. W. Q.
Burst: W, E, Basic Attack. Then, R and Q just before they are rooted.
1v1 Duel: E, Q, R, W.
Getting Ganked: R, W, E, Q.
Teamfight: R, E, W Squishy Target. Q. Basic Attacks.

This guide isn't very detailed but shows some of the basic features of Karma :) I hope I've helped and if you need any more advice try another guide :D Cya