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LoL Best Middle Build Guides 2025

Build guides for Middle champions on MOBAFire. Find recommended items and runes by high ranked players to learn the best Middle builds. Create your own champion guide!



2025, Season 2 Guides // Patch 25.12
9.5
232
Votes
48
LoL Champion Diana Build Guide
LoL Champion Diana Build Guide

#1 Diana SEASON 15 MID GUIDE!

Guide by Xalt updated June 18, 2025
  • In-depth
9.5
53
Votes
3
LoL Champion Irelia Build Guide
LoL Champion Irelia Build Guide

Blade Dancer Guide (FOR BEGINNERS)

Guide by xumi_k updated June 17, 2025
  • In-depth
9.5
345
Votes
29
LoL Champion Malzahar Build Guide
LoL Champion Malzahar Build Guide

[S15] Rank 1 Malzahar Complete Guide | By Coach xblademojo

Guide by xblademojo updated June 17, 2025
  • In-depth
9.5
866
Votes
48
LoL Champion Seraphine Build Guide
LoL Champion Seraphine Build Guide

❤ 🎶 [SEASON 15 NEW - 25.12] MASTER MID Seraphine! SEASON - THE SONG OF DEATH 🎶🎤

Guide by RezoneVerified updated June 17, 2025
  • In-depth
9.5
163
Votes
8
LoL Champion Akali Build Guide
LoL Champion Akali Build Guide

Anguishs GrandMasters Akali Mid/Top S15 Guide Patch [15.12] - Every Matchup/Item/Rune explained!

Guide by Anguish333 updated June 16, 2025
  • In-depth
9.5
212
Votes
22
LoL Champion Katarina Build Guide
LoL Champion Katarina Build Guide

[25.12] PrestigeGalaxy's 5M+ Mastery Guide to Katarina! 🗡️

Guide by PrestigeGalaxy updated June 12, 2025
  • In-depth
9.5
978
Votes
77
LoL Champion Kassadin Build Guide
LoL Champion Kassadin Build Guide

[15.2] Rank 1 Kassadin Complete Guide | By Coach xblademojo

Guide by xblademojo updated June 11, 2025
  • In-depth
9.4
110
Votes
14
LoL Champion Talon Build Guide
LoL Champion Talon Build Guide

[25.12] OTP Master Talon Guide with All combos / Season 15

Guide by AmiGo1v9 updated June 13, 2025
9.4
16
Votes
0
LoL Champion Twisted Fate Build Guide
LoL Champion Twisted Fate Build Guide

[25.12] Victorious Twisted Fate Guide for Season 15 | Jammed

Guide by Jammed updated June 20, 2025
  • In-depth
  • Featured
9.2
33
Votes
9
LoL Champion Kai'Sa Build Guide
LoL Champion Kai'Sa Build Guide

[25.12] LOADING SCREEN AP MID POKE KAISA GUIDE protein shakes are food

Guide by PalestinianLuck updated June 14, 2025
  • In-depth
9.2
2687
Votes
168
LoL Champion Heimerdinger Build Guide
LoL Champion Heimerdinger Build Guide

🔧[ 25.12 MASTER TIER 9.9 MILLION MASTERY HEIMERDINGER 🔧 SEASON 15 ]

Guide by RezoneVerified updated June 20, 2025
  • In-depth
9.2
54
Votes
5
LoL Champion Diana Build Guide
LoL Champion Diana Build Guide

[25.12] [Live] Best Midlane Diana Guide - Diimoonz

Guide by Diimoonz updated June 19, 2025
9.2
406
Votes
43
LoL Champion Katarina Build Guide
LoL Champion Katarina Build Guide

(25.11) Eriosun's Complete Master Katarina Guide - Season 15 [UPDATED]

Guide by Eriosunx updated June 12, 2025
  • In-depth
9.2
1980
Votes
128
LoL Champion Katarina Build Guide
LoL Champion Katarina Build Guide

[25.12] Nyro Challenger Katarina Build Guide

Guide by Nyrolol updated June 12, 2025
8.9
265
Votes
47
LoL Champion Ekko Build Guide
LoL Champion Ekko Build Guide

Power leon's guide for ekko players in mid lane

Guide by leonidas44 updated June 21, 2025
8.9
277
Votes
25
LoL Champion Cho'Gath Build Guide
LoL Champion Cho'Gath Build Guide

[Season 14] Sakuritou Challenger Rank 1 Cho'Gath World Guide

Guide by Sakuritou updated June 21, 2025
  • In-depth
8.9
647
Votes
51
LoL Champion Anivia Build Guide
LoL Champion Anivia Build Guide

👉 🧊[ NEW SEASON 15 ] - Master's Guide to Midlane ANIVIA! S TIER PICK! 🧊 👈

Guide by RezoneVerified updated June 19, 2025
  • In-depth
8.9
70
Votes
9
LoL Champion Nasus Build Guide
LoL Champion Nasus Build Guide

[25.12] Nasus Mid OTP - Simplest In-Depth Guide S2025

Guide by SurferKiller updated June 14, 2025
  • In-depth
8.9
89
Votes
11
LoL Champion Qiyana Build Guide
LoL Champion Qiyana Build Guide

(25.11) Eriosun's Qiyana Midlane Master Tier Guide, Rank 1 on the 24 Sisters - Season 15 [UPDATED]

Guide by Eriosunx updated June 12, 2025
  • In-depth
8.9
602
Votes
35
LoL Champion Azir Build Guide
LoL Champion Azir Build Guide

[Season 15] BodyThoseFools' Challenger Azir Guide [In-depth] (10,000,000+ Mastery Points) (Beat Faker)

Guide by Body Those Fools updated June 11, 2025
  • In-depth
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Teamfight Tactics Guide