Talon is usualy apreciated for his capacitiy to come into combat, damage and run. I usually like him when he comes in, kills and stays. Therefore I play him AD instead of AP, even though his Rake can hit a lot I prefer using Noxian Diplomacy for the high damage output.

Runes are the ones any AD mellee would use, including armor penetration, Critical Strike rate and damage, and attack speed.

Same as for runes, the masteries are the ones which I think are best for talon, and any AD assassin whi would be similar to him.

Because I play AD, items increase his damage, critical strike and attack speed. I usually end up with 100% Critics and around 2.5 attacks per second, at lvl 18.

I max Noxian Diplomacy first because it is that attack which will be most of my damage. I max rake second because it has consistent damage and slows down units, ideal for farming or micking up a kill, but not at level 13 because cutthroat helps a lot with the damage increase and the silence.