There are other good Twitch builds out there, and I'm not saying this is going to be some sort of amazing, revolutionary guide which is going to be better than all the rest. This is just the way that I play Twitch, and I find that it is pretty successful and works well for me. So without further ado, let's move on to the guide itself. For this purpose I selected

Build one

In this build I featured early game (and generally all-time) survivability, because it is when Twitch is most vulnerable. Being a squishy character, he needs all the extra survivability he can get in order to farm well to get those dps items he needs. For this purpose I put in flat health Quintessences, magic resistance per level Glyphs, mana regeneration Seals and armour penetration Marks.