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One being that Sheen is probably one of the best items for Vayne, especially early game. Going mid, or even laning, you can tumble and do double the damage another Vayne would do. Also, Sheen later builds into Trinity Edge, which is always good for a champion like Vayne.
Another thing I noticed were the boots. Although moving fast is fine, Vayne's passive already increases her movement speed when she sights an enemy, and it has decent range. I would probably go with Bezerker boots (attack speed) or Ionian boots (cooldown reduction).
Overall your build is fine though.
Probably not the highest ELO strategy, but for people looking to carry themselves out of the 1000-1200 ELO hell through solo queue, or find themselves unable to depend on other people to fulfill their roles on the team, or even just want to lock up the win early and force a 20 minute surrender, this is perfect.
Doesn't seem that beefy to me at all.