I have been experimenting with the New Dark Harvest on Rengar.

PASSIVE: Damaging a champion below 50% of their maximum health by any mean deals 50 − 80 (based on level) (+ 8 per Soul) (+ 25% bonus AD) (+ 15% AP) bonus Adaptive damage and reaps 1 Soul. This cannot happen again for 45 seconds, resetting to 1.5 seconds on champion Damage takedown.

This gives Rengar great lane trading against squishy champions, and with the Domination path you get extra lethality and damage, movement speed that helps rengar burst and roam.

This is my Rune Selection...
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