If you are jungling you should run 9x
Greater Seal of Armor, they will help you survive during your early clears, also there's no reason to take Lifesteal quint(s), imo you should run 3x
Greater Quintessence of Spell Vamp with 9x
Greater Glyph of Ability Power.I believe this setup should allow you to clear the jungle as
Karthus relatively easily.
As for masteries, you should not take utility masteries and rather try to get 9 points into defense, if you are having trouble jungling.
Also, you should replace
Morellonomicon and
Twin Shadows with
Void Staff,
Abyssal Mask or
Rylai's Crystal Scepter.




As for masteries, you should not take utility masteries and rather try to get 9 points into defense, if you are having trouble jungling.
Also, you should replace






If you have any questions, feel free to PM me.
Thank you, LevasK, I think I'll take your advice. Also, it's a raw AP build. I've been glass cannoning
Karthus, which works to great effect late game; but switching around my runes and masteries should give me that extra survivability i've been looking for in the beginning. Thanks!






If you have any questions, feel free to PM me.
Switched items, got
Void Staff over
Abyssal Mask, and got some armor runes to boot. This actually gets me more AP than the other build, thanks mate!


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Runes
I always get