But asuming you do have a level 30 account and you've gotten used to how the masteries and runes work, I'd like to point out that Greater Seal of Attack Speed are far from optimal and you would be much better off, picking something like Greater Seal of Scaling Health for AP opponents or Greater Seal of Armor for AD opponents. You say in the guide that you don't feel like you need defensive seals, but that goes back to what I was saying earlier about things changing when you get more runes and masteries. As others get more offensive runes, you'll need to get more defensive ones, to counter them.

As for the Greater Glyph of Scaling Cooldown Reduction you are using, I'd highly recommend swapping them for flat CDR ( Greater Glyph of Cooldown Reduction) as it will give you more CDR early in the game, when it matters and not later on when items will make up the majority of your CDR (and also makes your runes redundant as they go above the 40% cap anyways).

Now I don't really wanna throw another guide in your face as everyone else already has, but I use Greater Glyph of Scaling Ability Power to get the AP other champions get from their quints (which we use for the movement speed Twisted Fate so desperately needs). I do this because I feel like Twisted Fate doesn't really make that good use of the early CDR anyways. But again, that's a taste-thing and everyone is entitled to their own playstyle. Just wanted to point it out. :)

And as for you confusion why Greater mark of hybrid penetration would be better than Greater Glyph of Magic Penetration. It's because penetration from runes help a lot early on and later on gets "replaced" by items. And since Twisted Fate tends to auto attack a lot he benefits from having some armor penetration early on. It also makes it easier to CS. However this is also something I think is about preferences and I'm not saying it's wrong to take pure magic pen.

Now last but not least, Greater Quintessence of Movement Speed. It warms my heart that someone have finally realised why you need these. And the only comment I have here is that you should probably point out somewhere in the guide that Twisted Fate has extremely low base movement speed and that's why he needs the quints to position himself correctly.

So that's the runes done then. Now I'd like to point out that there is really no reason to build Athene's Unholy Grail as Twisted Fate already has amazing mana sustain with his Pick A Card(Blue card) and there are better items for getting Magic Resist if that's what you're after.

The other thing that catches my eye is the Nashor's Tooth, but judging from your runes and previous comments I'd say you probably play Twisted Fate as almost an adc which would justify why it's there. Btw I don't say that as a bad thing, Twisted Fate is a lot like an adc in many ways, due to him relying on auto attacks for everything but his Q( Wild Cards) and R( Destiny). I just tend to play him as more of a poke champion due to him being a bit tricky to position yourself with and having no escapes.
(Good on you for taking Ghost btw. Many others would have taken ignite and not realise how good the movement speed is)

Next up is ability sequence. I'm sad to say it, but the order you level your abilities in is horrifying. Twisted Fates E( Stacked Deck) is too good early game for CSing and poking, to not level up. You start with W( Pick A Card) which you also do, so no comment on that. But then we take Q( Wild Cards) second and max it first as it is the ability that the majority of our damage will come from. I just put a point into E( Stacked Deck), because as I said, it's very useful, just not worth leveling until last.

As for your masteries, the only thing I'd consider changing is putting the last 6 points into the resolve tree as Twisted Fate is not really an assassin and can't make full use of merciless] and [[dangerous game. But that's, again, up to personal preference.

Now one quick questions about your pros and cons. what do you mean by "good kiting and escaping"? good kiting yes, but the only escape he has (apart from Flash is Destiny and it has a long cooldown and cast time, making it more of a roaming tool really.

The summoner spells seems fine and I'll even give you a golden star for including cleanse.(not many people use this spell, especially pre 30)

I like the comical touch added by the skin chapter, but if you're serious about it you should add how different skins can actually have a gameplay inmpact. For instance underworld twisted fate has seemingly smaller cards, which might trick your opponents as the hitbox doesn't change.

As for the gameplay, I'd like something a little more extensive and definitely something more split push and objective oriented as that is where Twisted Fate shines late-game, map pressure.

All in all I think the guide, and yourself, are diamonds in the rough. You touch on many important concepts that a lot of other players would miss, but you still haven't gotten the true game-experience as you are pre 30.

I'd also recommend looking up how to bbcode, to make your guide look better. You don't need to make it extremely fancy as many other guides do, because to be honest that just makes it harder to read and understand the guides content. But Some colors here and there, and smart use of color coding, can be used to emphasis keywords and help get through the message you wanted to the reader.
Here are some link I highly reccommend checking out:
Bbcode
Making a guide
Ten commandments of writning a guide
guide basics
how to use columns
astrolias column guide
foxys tables guide
My Twisted fate guide, if you need any references. Also feel free to hit me up with a PM if you have questions.