* More than 50% of people will not look at the written section of a guide. Even if your target audience is the chosen few who go the extra mile, having notes for Runes and items (like you did in the "Full Damage" item block) is extremely helpful to get important information across in a concise manner;

* I would personally add an item block containing Control Wards, because vision is just that important you have to remind people about it (maybe inside a "First Back" block);



* As mentioned above, I'd put the banner before the Table of Contents. You generally want to make a big, flashy impression first (i.e. the banner) and only then get to the boring details (i.e. the index/ToC), although this is a minor nitpick and a personal preference of mine;



* In the above picture, I'd add newlines between the text and the pictures, just to avoid the "cramped" aesthetic, which is hard to read (this happens throughout the guide, this is just the first example). Additionally, I'd remove the purple lines on each advantage/disadvantage block, leaving instead a single separator to distinguish between advantages and disadvantages;

* The gameplay sections could use some expansion, as they are fairly basic and don't explain exactly how or when you need to do what you say. For instance, you say in the early game you want to play passive and go back when they go forward and vice-versa. What if the Pantheon decides to engage you? What do you do if the enemy is playing even more passive than you are? In the late game, where should you position yourself for best effectiveness? Things like that. Screenshots or videos would help tremendously in this department;

* You're also missing a section explaining item choices and when to build what.