Even if you don't die Good Hands is still better. Plus if you look at all the pro guides, and all the top ranked guides the Good Hands over perserverence. Late game if you die once its around 75 sec(exact formula is not known so I'm getting numbers from my past experiences)to get back in game. With good hands that's 7.5 seconds off which is a lot better than getting 4% MAX Health and Mana REGEN. 4% of 14 health regen, and 17 mana regen late game. That's about .56 health regen, and .68 mana regen per 5 seconds late game. Early game its .9 health regen, and 1.38 mana regen. That's about .036, and .0552 mana regen per 5. Compare that to lets assume you die around 4 times during a 45min game. Once during early , twice during mid game, and once during a team fight in late game. Early game 15 second death timer 1.5 seconds off. Mid game 42 second death timer 4.2x2= 8.4 seconds off. Late game 75 second death timer 7.5 seconds. 7.5+8.4+1.5=17.4 seconds off death timer compared to .56 health regen and .68 mana regen during a long game. I agree TheJohn on getting different type of seals. Get mana regen for when your harassing, or get armor seals. Also I feel like you should get RoA early to get its passive effect faster. You should have it built by 17min mark. Forgo boots, or mejais if you have to.

All good blud, but you do need atleast 1 point in molten shield to charge stun/hurt that Tryndamere that is being a gay ****. Also Catalyst before Blasting Wand is a better choice for building Rod of Ages, it gives you much more sustain in the laning phase, with every level giving you back ++ Health and Mana. To get the early kills you have ignite, a full tibbers combo to the face without a blasting wand is still 100% effective and pretty much guaranteed kill with ignite so much smarter to just get the sustain.

Good guide and I've seen it in action when I play with you.
-Syzrgy (Rowlad)

Did you try my build before commenting and downvoting? No? Then don't judge it badly and downvote it, void staff WAS mandatory before the Annie changes, it is still a great item, but this build focuses more on survivability than glass cannon, also the flat AP runes are for getting first blood / 2 or 3 kills early and to get the mejais going, by that time you should be getting fed enough to not need the rune AP anymore. Deathcap (in this build) is perfect timing, it means that despite your survivability increasing a lot, your mejais + RoA + RcS all get majorly buffed for extra AP, this build ensures that if you are a good Annie, you keep getting fed and don't die very often at all. Please try my build before downvoting.

AP/lv yellows and blues are way better than flat. Also deathcap should be gotten earlier. Annie is strongest early-mid game. Also voidstaff is mandatory.

As for tip #1 I'll be on that soon, tip #2, I don't often die... however you may be right about it for people who die a bit more. And tip #3, same answer as tip #2, I don't die often so I don't see the point of getting defensive runes (also as I have RoA, RCS, and ZH), i think there is enough defense in the items. And lastly tip #4, I almost always get mejais for the reasons above, I've played annie a lot and I can warrant it, however I have made a note that people shouldn't go to a mejais if they don't think they can get/keep the stacks up.

#1: Try to reduce the texts and use more colors, images, codes. Try to make the guide comfortable to read and make the person want to know what's coming.

#2: It's been proven that Good Hands is better than Perseverence , so get 3 points in the former and 1 in the later.

#3: As you can see, glyphs give more AP than seals, so it's a waste of IP buying 18 AP runes + 3 quints. Every kind of rune has a area it gives better stats.

#4: The build is good, but Mejai's isn't really recommended. It depends a lot on what's happening in the whole match, if they are focusing you or not and other factors. So try to give more options.

If you need any help, PM me. I'll try to answer as fast as I can.

You should really consider taking a point in Molten Shield a little earlier. Despite the drop in effectiveness from taking it over another point in incinerate/disintegrate, it can be used to charge your stun, as well as give a small advantage in 1v1 skirmishes.