Hi. This is Inferno2025 here, with my build on the champion Vladimir, the Crimson Reaper. Vladimir is a Tanky DPS character who primarily focuses on obtaining massive quantities Ability Power numbers to give him his Tanky Aspect.

You would not believe how many times I have seen Vladimir's in games use 'Troll' Pool to damage the current minions wave, then get ganked by a jungler and have no means of escaping. Please, please, please, please, please do not use your pool to do damage, unless you know you are ensured a kill and safe getaway, or are using it to avoid a gank. Thank you for your time, and have a good time in this build.

The Runes for Vladimir that I have chosen are:
Magic Penetration Marks
Ability Power Seals
Ability Power Glyphs
Ability Power Quintessences

*AP Quints Vs. HP Quints
-Vladmir's Passive give a bonus to you whether or not you use one or another. Some calculations that I have done to show that why I think that AP Quints are better for your health and damage, but still leaving HP Quints completely viable for your early game survivability.
-3 AP Quints = 15 AP
-3 HP Quints = 72 Health
Crimson Pact: Every 40 Points of bonus health gives Vladimir 1 ability power, and every 1 point of ability power gives Vladimir 1.8 bonus health. (does not stack with itself)
-72 HP ~ 1.8 Ability Power
-15 AP = 27 Health
Both of the Quintessence choices are very good on him, so its basically how you think you can play him.

I chose these Runes because the extra Ability Power helps Vladimir's early game by allowing you to lanestay longer due to the amount that it heals you when you are being harassed in lane. Also, the Ability Power will allow you do dish out some pretty serious punishment to your enemies if they get too close.

The Masteries on Vladimir that I have chosen benefit him to the greatest extent as I have seen. The Magic Penetration, Ability Power on Ignite, and 4% Spell Damage in the Offensive Tree make for great damage output when you are in combat. The Reduced time spent dead, improved Ghost, increased experience gain, and gold per five choices are also a good choice in my opinion by giving you increased utility when you do die, while laning and farming your creep score, and the extra little gold to help you get your items faster.

You can switch out your flash for Ghost if you please, as is why there is a point in Improved Ghost.

Amplifying Tome: Great early game AP and heal off of your Transfusion (Q)
Hextech Revolver: Amazing healing capability with your Transfusion
Sorcerer's Shoes: Magic Penetration is great on any AP champion, and helps against people who have Magic Resistance
Rabadon's Deathcap: What else is there to say?
Rylai's Crystal Scepter: This makes it so you no longer have to use Sanguine Pool to slow enemies in teamfights.
Will of the Ancients: Makes your Transfusion Healing even better than it formerly was, and gives all the other AP champions around you the same Spell Vamp effect.
Zhonya's Hourglass: This is one of my favorite items. Use it when you are in trouble, with your Sanguine Pool and Flash on cooldown, hopefully giving you enough time to let the cooldown reset on your Pool.
Void Staff: Just more AP and Magic Penetration. This can be swapped out for an item of your choice, depending on how the enemy team is.

For Solo 1v1 Fights:
Open up with aTransfusion (Q) then follow up withTides of Blood (E) at this point, they are most likey at 75% or less. UseSanguine Pool (W) to do some damage and to keep them from getting away as easily. When you come up fromSanguine Pool, use anotherTransfusion along with a secondTides of Blood, then position your ultimate,Hemoplague, to afflict them with the 14% increased damage from all sources. Use anignite on them to make full use of the increased damage from your ultimate, giving usually 3 seconds of increasedignite damage, with an extra tick on the damage to finish them off if they are rediculously low.
-Q,E,W,Q,E,R,D

For Teamfights of 3v3 or greater:
Try to pick one person out at the start. UseTransfusion on this person for the initial poke, get closer to the whole team and use your ultimateHemoplague for the increased damage from everything, along with aTides of Blood. Tides is your best friend in teamfights because of the low cooldown, high damage, and how it hits every enemy around you. If you start to get focused, useSanguine Pool to lose all of the immediate damage, and make your way to a safe place. Keep usingTransfusion on cooldown, as it is your main source of damage, and possibly use Flash orIgnite to pick up a kill if it is about to get away.
-Q,R,E,Q,E,W then D/F to pick up a kill

Summoner Spells that you should take on Vladimir:
Ignite - Helps ensure a kill with your R.
Flash - A quick getaway/pickup.
Ghost - Makes for easy towerdiving with combonation of Sanguine Pool.

Summoner Spells that you could take on Vladimir:
Teleport - It's nice to be able to hop lanes and get back to them quickly.

Summoner Spells that you should NEVER take on Vladimir:
Heal - you have your own, four second heal :/
Revive - Maybe in a Twisted Treeline game, but otherwise, no.
Smite - Vladimir isn't a jungler, come on.
Fortify - That's for tanks and big support.
Clarity - Really? Because Vladimir TOTALLY uses mana.
Rally - Nope, sorry. He's Not an auto attack Champion.
Cleanse - You've got 'Troll' Pool.
Exhaust - There's a built-in slow on Sanguine Pool and Rylai's.
Clairvoyance - Support mainly take this

As Vladimir, you should be farming HARD. Farming hard gives you more xp than your enemy if you can deny them, and LOTS of gold to get your items faster.

Think of it this way:
It's Fifteen Minutes in the game, and you have 112 Minions killed, along with the First Blood kill and a tower destroyed along with haveing killed the Dragon twice.
-112 Minions (saying you killed every minion except the siege ones) ~ 2800 Gold
-First Blood Kill = 400 Gold
-Tower Destroyed = 150 Gold
-Two Dragon Kills = 380 Gold
All of this Gold equals about 3730 Gold, which could buy you your Hextech Gunblade, Sorcerer's Shoes, Blasting Wand, with some left over for some Potions, Elixers, or Wards if you so desire to buy them.