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Aaaaah! The Ancient AP Skarner!
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just bare with me and il do my best.
Reds: Magic Penetration
Yellows: Mana Regeneration per Level
Blues: Ability Power per Level
Quintessence: Flat ability power
Skill order: E, Q, W, after that R>E>W>Q
Core Items Regrowth Pendant -> Philosophers Stone -> Merc Treads -> Rylais Crystal Scepter (Belt -> Rod -> Tome) AND/OR Nashors tooth ( Codex -> Stinger) -> Sheen
Philosophers stone? I really like it because you are very mana-hungry at first and you wont be able to really abuse your heal very well until level 5. The extra gold here also helps.
Deathcap & Lichbane or Zhonyas (not useful unless you get both, imo.)