I want to share this build because its works so well for me and i love playing vladimir.
I hope u like this build and works out for u too

For Runes I like to go for ability power and magic penetration because the ability power will help you very much early game and the magic penetration helps if you buy Ionian Boots of lucidity instead of sorcerers shoes. You can go for some cooldown reduction.

For masteries i go for Offense-9 and Utility-21. Offense for more ability power and some magic penetration and cooldown reduction. Utility for improved ghost and some other but you can build whatever you think is good.

I like to use Ghost and Flash. Flash is very good if u need to get out a fight with very low health and flash is also good if wanna finish enemies off and tower dive and then use the pool.
Vladimir is a slow champ so it will help alot with Ghost

Transfusion: It drains life of his target, dealing magic damage and healing himself. No cost




Sanguine Pool: He sinks into a pool of blood for 2 seconds, becoming untargetable and slowing enemies above him by 40% for 1 second, and deals magic damage over the duration plus heals himself. Costs 20% health


Tides Of Blood: He unleashes a torrent of blood dealing magic damage to nearby enemies.
Each cast gives him an Empowered stack (max 4), increasing his healing and regeneration by 8% per stack for 10 seconds. Additionally, his next tides of Blood deals 25% more damage and costs 50% more health per stack. Costs 30/40/50/60/70 health


Hemoplague: Vladimir infects the target area with a virulent plague which increases the damage nearby enemies take from all sources by 14% for 5 seconds. After these 5 seconds, infected enemies take magic damage. Costs 15% health

Go mid lane and try to last hit minions as much as u can. Vlad is very item dependent. Q(Transfusion) is a really good last hitting ability so try use it to last hit minions or enemies.

Now if u farmed well u should have Rabadons Deathcap and Rylais and maybe Will of the Ancients.
Its now the fun begins when u have very high magic damage and get much kills.

Now u will have all items and ur build is finish if u farmed early game and got some kills.

Pros

Amazing late game
High Magic Damage
Great Farmer Past Lvl 9
Great At Escaping

Cons

Squishy Early Game
High Cooldowns Early Game