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If you're not gonna use exhaust, why get Cripple?
Good point.
Also, all that movespeed... and no Priscilla's Blessing? PB would let you uncap enemy point very effectively.
As well, Twitch can effectively defend in a 2v1 at tower with lifesteal and attackspeed. With no lifesteal, Twitch will just die a lot.
To top it off, in a gametype like Dominion where you're racking up the xp like crazy, there's no point in wasting mastery points on Awareness . Would be better to just give him a little more defense in the middle tier.
For these 3 things, downvote.