Most of the games I run Conq+Resolve because you have more sustain than the Domination tree. The second wind rune heals you after you take damage and the unflinching its good because you get bonus tenacity and that helps you if you get stunned/rooted/taunted etc. On the course of years, I've developed my own runes that fit my playstyle the best. Like Domination + Sorcery (Elec + Absolute focus and Gathering Storm)