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Malzahar - Obey The Void Prophet
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9 Seals: +11 Mana Regen/5 at level 18
9 Marks: +8.5 Magic Penetration
1 Quintessence: -2.39% Cooldown at level 18
2 Quintessences: +3.78 Magic Penetration
Usefull Combination to keep you at lane with the Mana Regen.
Cooldowns gives you the bonus to have Ultimate very often. [48 sec CD at lvl 18]
Magic Pen allows you to focus tanks if needed [Don't forget your Null Zone]
If he's a slow player [reacts really slow] use Silence first, then Malefic Visions, Null Zone and your Ultimate, Nether Grasp. [Note: While you cast your ultimate you can use Ignite on him so if he had any chance to survive now it's gone]
If he's not a slow player and he avoids your Silence easily then use Malefic Visions first, then Null Zone right behind him [most likely he's gonna run back] and then Nether Grasp and Ignite. If he survives place your Silence on his way back or flash and use Malefic Visions again.
Another smart way to pick up a kill at mid is to wait until enemy's last creep is dead and Malefic jumps on him, use Flash to surprise him, Null Zone, Nether Grasp and Ignite and then cast Malefic again.
Ignite: An extra spell in your combo is always good, nice way to kill champions with high Lifesteal [Nocturne/Nasus] or Spell Vamp [Vladimir/Fiddlesticks]
In team fights focus their carry or their support. Use Call of the Void and Null Zone every time they are available. Supports like Soraka , Sona, Taric, Karma, Janna MUST be focused by you so they wont heal their allies or use any CC on your allies.