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But I have to agree with some of the previous posters that those runes are off.
The item build is good, but would agree with Hyfe's guide over this where they deviate.
An early glacial shroud (later into Frozen Heart) and perhaps kindlegem (later into Shurelya's) gives you an early extra 25% CDR letting you build your Q up faster.
The Shurelya's (that active is awesome for Nasus as well) and Frozen Heart will get you up to the 40% cap letting you dish out more Q's in fights.
I would also say that dodge seals and nimbleness mastery is too great to give up for some mana regen that you really shouldn't need.