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But in theory, Meki Pendant will be better for mana regeneration 200 seconds after you've cast your first spell. However, this is assuming that you're never at full mana, in which case any mana regeneration is wasted.
The Sapphire Crystal, on the other hand, increases the maximum amount of mana, so that you won't have full mana as often.
Also, if you're laning with a mana-user, the Sapphire Crystal makes it easier not to waste any mana given by Clarity, should your lane partner need it.
Also, I haven't played much late-game with Orianna yet, but I can't see any problems with taking Zhonya's Hourglass. I've tried to experiment with some Spell Vamp on her, but the games tend to to be over when I've made the Rabadon's Deathcap :)
Hope it helped! :D
but 2 quick questions
instead of starting with a saphire crystal, is a meki pendant fine?
and also is it okay to replace Void Staff with Zhonya's Hourglass? because the active is pretty good and it also adds on more AP
thanks :)