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Spells:
Teleport
Flash
Ability Order
Clockwork Windup (PASSIVE)
Orianna Passive Ability
Runes
Here's why:[/center]
Marks: Orianna has a strong game throughout, but an especially strong early game. This is why the flat magic penetration bonus provided by 9x Greater Mark of Magic Penetration is valuable.
Seals: She has constant mana problems. I use Greater Seal of Scaling Mana Regeneration to help solve these, but Greater Seal of Replenishment also works well. Another factor is the cost: Greater Seal of Scaling Mana Regeneration is cheaper.
Glyphs: Orianna desperately needs CDR. It improves her game soooooo much. For glyphs, Greater Glyph of Scaling Cooldown Reduction or Greater Glyph of Cooldown Reduction are really her only two options. It just depends on which you prefer. I use Greater Glyph of Scaling Cooldown Reduction because it is cheaper.
Quintessences: Early game especially, Orianna is SQUISHY. Thankfully, Greater Quintessence of Health solves this problem. You can use three of these if you want, or you can mix in other runes such as Greater Quintessence of Movement Speed, Greater Quintessence of Magic Penetration, or Greater Quintessence of Ability Power. I went with 2x Greater Quintessence of Health and 1x Greater Quintessence of Movement Speed because Orianna is a pretty slow champ when she doesn't have the mana for her W.
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