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Lux can be very dangerous to gank or lane against. Since she can stun with [Light Binding], and from that point allowing other Champions to corner you. Play stratgically against her.
Kassadin
Kassadin can be a very dangerous champion towards Rek'Sai. If the Summoner is experienced with Kassadin he can extremely annoying to fight against, since his Ultimate can chase you down.
Bard
Bard the kind of Support prone to help his Team chase you down. He can be both aggresive and defensive, always try poke him.
Master Yi
Master Yi is another champion that can prove diffucult to lane against and escape. Always try to keep your health full against him.
Morgana
Morgana is another Support that can be extremely dangerous towards Rek'Sai. Since she can snare you, you should always try build some magic resist.
Twisted Fate
Twisted Fate is a Champion that can be unpredictable both in Build and Playstyle. Always be cautious against him.
Cho'Gath
Cho'Gath is a Champion that can stop you from engaging. Try to keep distance away from him. Try to poke him out of his comfort zone.
Lucian
Lucian CAN be a dangerous champion against Rek'Sai. If the Summoner is an experienced Lucian Player, play defensively towards him, always try to poke him.
Vayne
Vayne is a Champion that can always prove a high threat towards Rek'Sai. Since she can chase you, always try to keep distance but don't allow her to get the upper hand. Try to poke her, but it all depends on how you chose to engage, vice versa.
Thresh
Thresh, can pull you towards him, allowing enemies to corner you. Play safe against him, always try to keep an eye on his and his laning partners Mana. If you see an oppertunity to kill or hurt Thresh, take it. But only if he is alone. That's what i do.
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