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1. Time warp Tonic
- I agree that this is an underrated rune, especially for Karma, who is very squishy. Though she might have heal in her arsenal, this is a team game, and as an enchanter support, you have to keep your team alive so you have to always think twice where to use your Mantra. This rune helps in sustaining you in lane and sometimes the enemy team gets caught off guard thinking that they could kill you lol.
2. Rushing Tier 2 boots (Ionian boots)
- We know that Mobility and CDR is important to Karma and rushing this item will help you harass more in lane which brings me to third point
3. Pushing the lane to enemy tower
- Not only does this deny the enemy adc CS, it also helps you aim your Q or Mantra Q on the enemy
Again, I appreciate this guide. Give this guide a try!! I started being serious in rank this season and this has gotten me double promotions (Silver 3 -> 1). Thank you!