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1- change your attack speed and damage runes for either crit or armor pen. atm you have 191% attack speed. You're forgetting the 40% attack speed gained from Teemo's passive. you're effectively wasting 30% of the gain from his passive bonus.
2- Malady certainly is great with an as/ap hybrid build, but either a Madreds or Youmuus would server better given the AD nature of your build.
3- in your masteries, points in Brute Force and Hardiness are better spent in the utility tree. 5% experience and 15% neutral buffs are far more useful. longer lizard/baron buff = more killing potential.
-1 for lack of Optimization. But i'm a rating nazi, so don't be too mad because i've only +1'd 5 builds on the site.