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Important: This guide will be updated (!)
It all comes down to a common misconception: People tend to start their combo with Q. Cho'Gath Q is actually a really hard spell to hit, specially in modern league.
The full Cho'Gath combo is:
1.- W - It silences the enemy, preventing any dash or flash.
2.- Everfrost Active - If you land it, the silenced enemy will be also rooted, making Q an effectively undodgeable ability (failing the root will slow the target anyways, so you can still easily hit it).
3.- Q - Huge knock up and damage, at this point the squishy is almost always doomed and thanks to approach velocity you will be already on top of him.
4.- E - While knocked up, Hail of blades attack-speed will proc, and you'll chunk them with Flat & Max HP Magic DMG + Muramana enhanced AD. One Autoattack is enough most of the time for squishies to enter execute range before they even hit the ground, as your combo already carries fat dmg; if not (Ex: Shieldbow/Seraph's), just dump the three enhanced autos on 'em.
5.- R - Enjoy your meal!
(Conclusions: Upgrading W will prolong the silence and your window for strike with everfrost+Q)