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Spells:
Ghost
Exhaust
Ability Order
Love Tap (PASSIVE)
Miss Fortune Passive Ability
Introduction
**Update 03-02-2012**
Updated to newest META as well as improved Runes, Masteries and Items!
I appoligize for the layout, this will be edited when I get to this matter.
Thank you for taking a look at my build, please read before !
First I will explain to you why I went for certain Runes, Masteries or Items. I will also give you some tips on handeling the opponent's team.
This is my first build, so please be gentle and please leave comments if you have ANY complaints.
One day, young Sarah returned home to hear gunshots and screaming. Her front door was smashed open; inside, she saw her mother lying in a pool of blood. A sudden blow to her head made her collapse next to her slain mother. The last thing she could remember were her attacker's red eyes, as his face was blocked by a rogue's bandana. Miss Fortune has a strong distrust for pirates and she finds herself constantly bickering with the infamous Gangplank (the only captain to resist her charms) over the direction of Bilgewater politics. Her two goals: to unite the people of Bilgewater, making them into a strong and independent society, and to find the pirate who killed her mother. To that end, she has entered the League of Legends as a champion, trading her skills for the wealth and influence that will help her accomplish both.
Pros:
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High-ranged Champion
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High damage output
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Has a nice Passive which makes you hard to catch
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Incredible harresment early game
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Great for farming
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A nice ultimate that can turn teamfights
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Both single target attacks and AoE attacks
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Can do Mid, Top or Bottom, it doesn't matter
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For most of the guys: She is really hot and has nice skins
Cons:
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Very squishy
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Slowed down when hitted
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Mostly Targetted in teamfights
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Has no escape abillities except her movement speed

Followed by Seals:

Other viable options are:
greater seal of replenishment If you need some extra mana early game, to ensure you can spam "let it rain" or "dubble tap".

If you just want that extra armor when you are playing against another ranged champion, this makes you get less impact and ofcourse makes it able for you to do more damage to your opponent then your opponent does on you. Which means you can either pick up a kill or make them have to go back. I mostly pick these when I play draft/ranked and know weither my opponnents are mainly AD or AP.
Other viable options:
If you'd like to just have alot more base mana instead of recovery, I'd have to say: Go for it. It's obvious that this Glyph is pretty strong compared to the glyph of replenishment, however once you go out of mana, you will have to endure not getting great harresment.
Just as with the Armor Seal, it's very nice. Gives you that extra endurance which you might need against another ranged damge dealer. I mostly pick these when I play draft/ranked and know weither my opponnents are mainly AD or AP.
And last but not least, the quintessence:
At the top I put in 2 viable options:


Most low level players don't know that they need to have a tank in the team and they don't have any Armor/Magic Resistance Items, Runes or Masteries. That's why I recommend low level summoners to get this quintessence instead of armor penetration, since armor penetration won't leed to alot more damage.
When you completely max out that offence tree, there are 8 points left. These points are well spend into reduced deathtime and movement speed.
As I explained at the Runes it gives the sustain to keep poking both close ranged as well as long ranged champions. Dubble tap has a huge range that "normal" ranged AD carry's don't have.
Other viable options are:
You might also want to go into the defence tree a bit, just to get that extra sustainabillity , but unless you are playing a high level game, I wouldn't recommend it.


Since the new masteries came out, critical damage first got a nice boost, and later it got nerfed. I am getting Zeal first, because I want my damage and sustain to be more important!

So... You got all those items? Good boy/girl! Now here are also some highly recommened items for you to finish this build with:

Survival problems? Take Frozen Mallet, if it isn't enough take one of these:
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