Well, this is my first Guide about my main champ, TF.
I dont play him pure AD or AP, i just play him the way i like :)
I hope you enjoy it!

I myself chose ArPen runes for the autoattacks ( who'd think of that?) MReg runes, especially for the early game and some AP runes to boost them a little bit.

simple 30-0-0 Masteries, I think it's quite easy to understand why i chose these. We need some AP, AD , ArPen, Lifesteal and some Dmg for the tower.

So... As you can see, i take items which give me Attack speed at first place. This fits great into our E spell, which gives us lots of dmg at every 4th hit. Wit's end + Malady give us +62 damage with each hit, increase your MagRes and decrease the opponent's one. Our Bloodthirster gives us a nice bunch of AD and Lifesteal, do i need to say more?..
Ionic spark. In my Opinion the best item for Twisted fate. it gives us a bit more life, good attack speed and the best of it, the passive. Every 4th hit ( remember our E?), there'll be a spark which deals 110 damage to all enemies near our target. GREAT for teamfight, GREAT for farming.
the 6th item is your choice. i personally love the hextech, because it gives you all you need, some AD, some AP, Spellvamp and more lifesteal.

Passive: we get 2 gold extra for every killed enemy.
-> not the best passive but it helps your whole team.(Your jungler will like it!)

Q Spell: TF fires 3 cards conic, dealing damage to all enemys pierced by it.
-> good harass, maybe a bit tricky aiming, but all in all good spell.
W Spell: over TF's head, you'll see a card changing its colour. RED->GOLD->BLUE->RED->..
Whem you press W once again, you pick the recent card.
gold -> Stuns the enemy for 1 second.
-> VERY good harass. Stun the enemy, give him a Q, maybe some auto attacks, continue farming.
-> Someone tries to towerdive you? Stun him, kill him!
Blue -> the next attack will fill your mana for 65% of the damage.
-> Low mana? Blue card a minion and feel free to spam your abilities!
Red -> does damage to near enemys and slows them
-> If you get ganked by more than 1 enemy, cast it, slow them, run away or kill them.

E Spell: (passive) with every 4th hit, Twisted fate does extra damage to the enemy. His attack speed gets increased and his cooldowns get decreased.
-> i max this first because of the bonus AS, Damage and the CDR.

R Spell: Let you see all enemy champions for 6,8,10 seconds. in This time, you can teleport to a place 5500 units far.
-> good if you think the enemy do Baron, switch lanes,backdooring, finishing single enemys or unhide ganking when your Carry is pushing alone.

This is all. I hope you enjoy the guide and comment it about positive and negative aspects. We are all only humans. (: