Best Vayne ADC Build Guides 2025 for LoL Patch 25.11

Rating Pending

Hyper Carry Vayne 1 Tabs
Build by WhisperOfEternity updated February 11, 2024

Rating Pending

Vayne Builds and Runes SEASON 14
Build by Tore updated January 18, 2024

Rating Pending

[14.2] Vayne - Full life Steal
Build by Chironex updated January 19, 2024

Rating Pending

[Season14] Vayne 1 Item Power Spike
Build by YKrow updated January 12, 2024

4.9

7
Votes
18

Master Vayne Guide 13.21
Guide by Trixiefix updated November 25, 2023

9.5

3093
Votes
225

Season 13 - Vayne Guide - 13.20 Patch [Updated] [Ready]
Guide by Proxxii updated October 19, 2023

8.1

6
Votes
0

Season 13 ULTIMATE Vayne Guide. Every Build.
Guide by mythicdem0n updated September 4, 2023

Rating Pending

The Quintessential Vayne Guide: Walls, Rings, and Late Game
Guide by TheRealVayneGod updated September 2, 2023

8.3

120
Votes
20

Reptile - EUW Challenger #1 Vayne ADC Guide (Patch 13.16)
Guide by Reptile9LoL updated August 21, 2023

In-depth

Stream

Rating Pending

vayne
Build by acredis updated December 27, 2023

Rating Pending

Vayne OffTank
Build by Bobabz updated November 8, 2023

Rating Pending

Play Like ACE/ New School Vayne
Build by Imace updated September 1, 2023

Rating Pending

[13.14] VAYNE ONE SHOT - SPAMMING Q
Build by Bloush updated July 28, 2023

Rating Pending

Vayne OTP build S13.8
Build by fecusss updated May 3, 2023

Rating Pending

[P12.23-S2022] BOTLANE ADC VAYNE CAPTAINEVOX
Build by Captain EvoX updated March 26, 2023

Rating Pending

vayne
Build by Kirishima558 updated January 26, 2023

Rating Pending

Will be updating Vayne Counters season 13 / Simple Vayne Build
Build by 400APFT updated December 30, 2022

8.1

17
Votes
4

Tank & AS Vayne
Build by Reformed_Jardys updated November 21, 2022

Off-Meta

Rating Pending

True Damage Vayne
Build by 400APFT updated December 6, 2022