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LoL Best Vayne Middle Build Guides 2024

Build guides for Vayne Middle on MOBAFire. Find recommended items and runes by high ranked players to learn the best Vayne Middle builds. Create your own champion guide!



Season 13 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Off Meta Vayne

Build by Crab Guy updated March 22, 2023
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

3 Shot Sorry didn't mean kill you

Build by 400APFT updated December 6, 2022
Season 12 Guides
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne mid, let us hunt those who have fallen to darkness

Guide by SaltCat updated June 13, 2022
  • Off-Meta
Season 12 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Lethality

Build by I TEACH YOU TO LIVE updated August 11, 2022
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

how to get zero bit*hes as vayne

Build by apo fcking red updated August 17, 2022
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

vayne

Build by cmenblaster updated March 26, 2022
Season 11 Guides
8.8
17
Votes
2
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Calculus Optimized Vayne

Guide by fanchessfan updated August 7, 2021
  • In-depth
Season 11 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Mid

Build by MeechyDarko updated September 10, 2021
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Lethality Vayne Mid S11

Build by InstalockVayne updated August 9, 2021
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Chad Mid Vayne S11

Build by InstalockVayne updated August 8, 2021
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

test

Build by fanchessfan updated July 4, 2021
  • Off-Meta
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne: I Am Lee Sin (Mid/Top)

Build by Aht3ns updated April 14, 2021
  • Off-Meta
Season 10 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

baddest ***** on tiktok

Build by Manny poo 69 updated August 28, 2020
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne MID

Build by 8LyThE updated February 4, 2020
Season 8 Builds
7.5
6
Votes
1
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Midlane

Build by TsarMaestro updated December 23, 2017
Season 7 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

400k Vayne Guide

Build by Elisoboy updated December 10, 2016
Season 5 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne ARAM guide

Build by zLgC updated September 16, 2015
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Stun, Pew-Pew-Pew. Dead.

Build by tristantmk updated February 16, 2015
Season 4 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

APC Vayne

Build by MCBUDDER updated March 25, 2014
Season 3 Builds
Rating Pending
LoL Champion Vayne Build Guide
LoL Champion Vayne Build Guide

Vayne Riot Guide

Build by Tylork updated September 6, 2013
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