YOU ARE GONNA PWNEDDDDDDDD EVRYBODY!!!!!!!! :D CAUSE YOU ARE THE LEGENDARY KILLER!!!!!!! VLAD IS THE BAWS OF THE BAWS!!!!!!!! vladi vlad vladimir vlad-vlad big-vlad big-tony

You should try to have many kills if you want to buy items early and the earlier you have the items the earlier you win so dont be shy to KS :D

Vladimir is a champion that can stay long time without recalling to do that try to only use your Q and rarely your E or your W to escape from ganks and other things like that.

When you use your Q it's better to use it against a champions because even if he attacks you, you will regain an amount of your HP.

The best way to use your E it's when at least you are some spell vamp, use it at the middle of enemies minions.

Ninja patch nerfed Vladimir's Sanguine Pool damage down to
-Magic Damage Per Half-Second: 20 / 33.75 / 47.5 / 61.25 / 75 (+3.75% of bonus health)

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-Transfusion cooldown reduced to 10/8.5/7/5.5/4 seconds from 12/10/8/6/4
-Crimson Pact ability power to health conversion reduced to 1.4 from 1.8
-Hemoplague no longer costs 15% of your current health and is now no cost to cast
-Tides of blood health cost ramp up reduced to 25% from 50%

Passive: Crimson Pact: Every 40 points of bonus health gives Vladimir 1 ability power and every 1 point of ability power gives Vladimir 1.8 bonus health (does not stack with itself). [/color]

Q: Transfusion: Vladimir drains the lifeforce of his target, dealing magic damage and healing himself. (600 Range)

W: Sanguine Pool: Vladimir sinks into a pool of blood for 2 seconds, becoming untargetable and slowing enemies above him by 40% for 1 second, and deals magic damage over the duration plus heals himself for 12.5% of that amount. (~350 radius)

E: Tides of Blood: Vladimir unleashes a torrent of blood dealing magic damage to nearby enemies.
Each cast gives him an Empowered stack (max 4), increasing his healing and regeneration by 8% per stack for 10 seconds. Additionally, his next tides of Blood deals 25% more damage and costs 50% more health per stack.

R: Hemoplague: Vladimir infects the target area with a virulent plague which increases the damage nearby enemies take from all sources by 14% for 5 seconds. After these 5 seconds, infected enemies take magic damage.

Ahri can knock you around if you aren't careful. Make sure you take Movement Speed quintessences if possible, as they help you chase her down and dodge her skillshot oriented kit. Start with Boots of Speed and constantly move to avoid her Q. Push onto her early with Transfusions and she'll be an easy fight. Don't let her get ahead, keep her pushed with Q, dodge her taunt and you'll be victorious.

Anivia is one of the easier to combat foes, granted you purchase Boots of Speed and 3 Health Potions as your opening items. Constantly remain mobile, and harass her with your Transfusion when you can and the lane will be yours; if not, you're in for one of the worst lanes of your life. Beat her down before she's level 6, and she won't be a threat at all. She pretty much just gives you snow by the shovelfuls to make snowballs with.

Annie one of the most lenient casters in the game which gives you a large margin to make mistakes as her. Molten Shield will cause her to live by ridiculously low amounts of HP, and her short cooldowns and stun will wreck you early game, and will make it extremely difficult to win later. Again, unless he sucks or you REALLY know what you're doing, swap lanes or get ganks as much as possible.

Brand has the capability to dominate you without before you can say '****.' Like Ahri, take Movement Speed quintessences to avoid his Pillar of Flame+ Sear combination. His itemization helps you win this lane, as he'll most likely purchase a Doran's Ring, which extremely limits his sustainability. Use Transfusion on him as much as possible, avoid Pillar, and you'll be fine. You can use Sanguine Pool to completely negate his ultimate if its coming to you. Do this in lane, and team fights- as you will save your team many deaths.

Cassiopeia..... Nearly impossible to lane against in middle. Her sustained damage will shred every part of your existence. Low cooldowns and a stun spell death for you. Again, avoid this lane. Tip: If you listen, Cassiopeia lets out a gasp .65 seconds before she casts Petrifying Gaze; if you can Sanguine Pool before then, you'll avoid most of her burst.

Fiddlesticks isn't as scary as everyone makes him out to be. He's limited by the mana system, while you are not. Push him around at level one with your Transfusion, then play carefully. Try to use your spell rotation on Fiddle AFTER you see him Drain a minion. This will limit the damage he can do to you- but don't be afraid to fight him when he has his combo up. Passive gameplay with Fiddlesticks will show him that he has the advantage, and he will press this as hard as he can. Don't kill yourself with Tides of Blood and this lane is yours.

Heimerdinger has potential to dump anal rockets right down your mouth. Kill his turrets with Transfusion, it rewards you with great amounts of gold. Steer clear of his turrets once he's level six, and try to stay behind three minions at all times. His main source of DPS is his rockets, and they target the three closest hostile units. Negating most of his damage is easy, you just need to be very cautious.

Karthus is a double-edged sword, and he's famous for it. Kill him, he'll most likely kill you after. Stay inside your minions to avoid the 2x damage from Lay Waste, and poke him with Transfusion whenever you won't lose too much health from it. His ultimate, Requiem, can be dodged with Sanguine Pool. Count to two as soon as you see him channeling and push W. This negates the damage from his ultimate, and allows you to bait his Champion Farming tool. Movement Speed quintessences do well here, as do Spellvamp. Take your pick.

Kassadin, his early game range and silence will shut you down. There's no way to counter him as Vladimir, as he trumps you at every turn. Unless he sucks, you're going to lose. Swap lanes if possible.

Kennen is a laughable opponent for Vladimir. You're both the same mage archetype (Tanky AP) which gives you room to either win or lose, as you are both phenomenal snowballers. This lane is dictated by the first kill. Whoever gets their Hextech Revolver first wins. Stay behind minions, poke him with your Transfusion and make him pay for trying to stun you. He has a small health pool, so play aggressively (not stupidly) and you can come out with decent stats.

LeBlanc, extremely bursty and will shoot you down starting at level two if you are not careful. I have played multiple games against her with great results. As usual, buy Boots of Speed and three Health Potions with three Greater Quintessence of Swiftness and this lane will be yours. Abusing your high mobility, you can dodge most of her Distortion or Ethereal Chains attempts to proc the silence+bonus damage on her Q. Bite into her with your Transfusion as much as possible, but don't overdo it; try to maintain 3/4 HP in this lane. Taking Heal as a summoner spell will also help counter her especially hard. Kill her before level 6 for an easy win, but if you cannot do that, get a gank. She doesn't get too out of control until level nine. The key to winning this is a fast tower push, as LeBlanc's game lies within the laning phase.

Mordekaiser capitalizes on passive/scared gameplay. You need to be aggressive, but not reckless, if you hope to win this lane. As with LeBlanc, take as much movement speed as you can get to counter his limited casting range on his spells. His kit forces him to push the lane if he wants to harass, so use this to your advantage. Transfusion him as soon as you get into lane, and continue this. Constantly moving is what makes you an excellent counter to Mordekaiser. Try to get him outside of a minion wave if you want to go for a kill, unless you are confident you can kill him with the possibility of his shield coming up. Level six is where the problem lies with his burst rotation, so try to get your Null-Magic Mantle for that extra bit of Magic Resist. Rush a Spirit Visage after your Ionian Boots of Lucidity and Hextech Revolver for a safe victory.
NOTE: You may need to buy Sorcerer's Shoes if he has Magic Resistance runes/items.

Morgana is only a threat if you play passively and allow her to become one. If you pick up Boots+3 Health Potions as your start, then you constantly harass with Transfusion, she won't be able to hit her stuns, which will cause her to dump her mana. Because of this, she either has to go back; which gives you time to push her tower, or permits you to get a kill on her because she's defenseless. Dodge her Q, You win.
A good technique to counter this **** is to look at your Debuff bar when she uses Soul Shackles, and then use Sanguine Pool when her ultimate is just about to trigger. This allows you to negate most of the stun.

Ryze, like Annie, has short cooldowns. However, he only has to build Mana, and most of the mana items also have resistances with them. Extremely difficult to lane against, but it is possible.

Viktor has amazing control over the lane with his overall skill kit, but can easily be forced back after his combo is dumped; due to having optimal damage output through quick spell casting. This can be deterred using Sanguine Pool, but will often cost you your life if you do not time it perfectly. Handle with caution.

Ziggs... ಠ_ಠ Be extremely careful