When you are at the mid lane, you can easily harass your opponents with transfusion if they get close or you just need to step.

Before you charge on you opponents make sure you've stacked up tides of blood a little so that you will deal more damage. and when you advance you would have had to harras the opponent before you charge at them..

in level 6 is a great time to charge with your hemoplague ready first you start of with Transfusion then goes in with Sanguine pool then you use your stacks of tide of blood to bring him low and another transfusion.. then you finish your opponent of with a Hemoplague..

If you are ganking with Vladimir it is best to open up with Saguine pool and then tide of blodd and then Transfusion. If they escape alive, make sure to put hemoplague on them before they leave so they will have a certain death.

It is real easy to farm with vladimir with all his abilities you can easily farm minions and creeps. if you see a minion with low health Either go for Transfusion. if u see a group of minions with low health you can use Tides of Blood first then Sanguine Pool.

And if that opened up for you enemy to charge u just use exhaust if it's real necessary, or you will just drain health from you enemy mid champion with Transfusion