To start, don't complain with "Vlads OP Nerfing soon" cause as im depressed enough to say, vlad is getting his Q nerfed. ANYWAYS, vladimir is by far one of the best nukes in game behind ryze if he is. OP ultimate and Q and his W and E just dominate everything, being untargetable and both being mega dps aoes. Vladimir came out when i started LoL and from level 5 when i bought him, he has been by far my favorite champ EVER! I hope you enjoy the guide :D.

Pros:
Can TANK and DPS.
massive damage output.
damage increase to targets inflicted with ultimate. (Not looking so no percentage =/)
Mega harass.

Cons:
Bad early game.
susceptible to hp percentage damage, Ex. Madreds Bloodrazor.

Ignite: this plus his ultimate on targets at about 15-20% hp will be put out of there misery by this combo.
Flash: i think this plus Sanguine Pool (W) can basically get you out of any situation unless there happens to be someone on the other side with a potent cc.

OPTIONAL:
Ghost: can be more viable then flash in some situations, if it suits your preferences, go for it!
Teleport: Midding is where Vlad shines IMO. and if your low on hp you can just go B and get back immediately reducing Turret damage.

I would say more but i really can't think of any more viable spells off the top of my head.

Vlads fairly easy to play and his combo is just as easy and still as devastating as a ryze combo for instance.
Combo: Q->E->W->Q->E->R->Ignite

getting that kill during laning phase.
1. Soften them a bit with Transfusion (Q). About 75-65% is good.
2. Flash if there out of range.
3. COMBO!!!!
4. If they camp the turret just wait till pool to FINISH THEM!

Well thats it... This is my first build so please tell me if anything is complete ****. I hope you enjoy Vlad as much as I do and yall best be dominating those Fields of Justice if your gonna play him :P.