First of all, please excuse my grammar mistakes. English is nmot my native language. Ok Vladimir is an AP-Off-Tank. He is propably the most unique champ of the league. In the following chapters I try to teach you something about how to play Vlad.

*Greater Mark of Insight
*Greater Seal of Vitality
*Greater Glyph of Force
*Greater Quintessence of Potency

Marks: Pretty logic I suppose. Other possibilities are Greater Marks of Force and Greater Marks of Fortidude.
Seals: Scales very well with his passive. Other viable runes are: Greater Seals of Force and Greater Seals of Fortidude.
Glyphs: Perfect AP Runes. You gain a nice amount of AP. You really need them too much to take others. If you really hate those awesome runes, you might take Greater Glyphs of Focus. But i dont recommend any other runes than AP/LvL.
Quintessence: There are two possibilities: Greater Qunitessence of Potency and Greater Quintessence of Fortidude. Both are very strong early on, but both loose much power later on.

Ionian Boots of Ludicity - Strongest Boots for Vladimir
Will of Ancients - Best Item for any Vladimir. Seems like it just exists to make Vlad viable.
MORE FOLLOWING SOON