Personally I have never bothered to buy any and I'm thankful that I didnt blow IP on them. CDR glyphs are pretty dang expensive. I also would use them on approximately 0 champions, so I don't plan on buying them any time soon.
MR or AP tend to be better for mid laners. MR/lvl is better for junglers.
MR or AP tend to be better for mid laners. MR/lvl is better for junglers.

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is it worth it to have cooldown quintess or glyphs? or is it more viable to go for flat ap damage