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About phantom dancer, i'm not sure why you stay away from it, but i find it to be a really nice item when paired with infinity edge. And runaan's 2 AAs don't work with spray and pray. Also the range of the projectiles remains the same, so if you are using your ult to attack someone that is really far away, you won't even use those 2 projectiles.
I didn't really understand the last question from your first comment, but if you ask me what to choose between the black cleaver and a defensive item, i would go for the defensive item if the enemy team has some gap closers or fed assassins. If they don't have something like that, instead of black cleaver i would like to end with a blade of the ruined king. It gives you even more sustain, and a nice movement speed boost to run away from your foes. Also in late game, champions tend to have a lot of hp, so this item could prove even better than the black cleaver, but i have to admit that the cleaver is an interesting pick ^^. Oh and i forgot about the attack speed that would work really well with all the damage you already have.
I've like going full offensive items when I get feed at the start of the match, makes Twitch impossible to deal with, though super squishy if not positioned properly. I usually stay away from runaan and phantom dancer, and go with bloodthirstier, berserker boots, infinity, last whisper, statik and then either black cleaver or a defensive item (gardian angel, banshee's, frozen mallet or randuin; what would you use instead of the defensive item or black cleaver?
Wmvv93 I haven't tried runaan but if you like it, who am i to tell you to stop using it?^^
I use the shiv because i find the 20% crit and the magic damage much more beneficial than 2 AAs that actually deal the damage of one, and also because of the synergy it has with botrk (more attack speed, more magic damage), but i guess runaan's has this synergy as well.