Incase you missed any notes along the Guide:

Summoner Spells

.Flash and Ignite- General go to due to karma's agressive laning phase.
.Flash and Exast- Good if you want to shutdown a specific carry.

Starting Items

.ALWAYS take Spelthieves Edge on Karma, there is not a single lane in the game i can think about where relic shield would bennifit you over the former option. You are a lane bully, if you going to sit back and "afk the lane" dont play karma, try someone like sona, soraka, lulu or anyone else that scales well into the late game.

Mythic Item Options

Enchanter Items

Karma can use all 3 support enchanter items although some work better than others. The best mythic items for karma are Echoes of Helia and Shurelya's Battlesong. In games where you are ahead and can reliablily hit your enemies with damage to proc the item's passive, Echoes of Helia will be the better option. Shurelyas on the other hand is always a good and consistant choice, when ahead or behind, and has the added benifit of providing very good engage or disengage potential for your team with your mantra+shield. Moonstone Renewer is also a viable mythic on karma, although its heavilly outshined at the moment by the other 2 options. This item is better on enchanters that have both healing and shielding in their kits, karma can only chain her shields, making the value of the item lower than if it was picked by someone like Sona or Soraka.

Alternative Mythic Items
In most cases karma's prefered mythic items are the 3 enchanters items listed in this guide, although she can make use of these 3 mythic items in niche situations. In cases were you facing very heavy burst damage, and teamfights are very short (therefore getting no value from other mythics, like Echoes of Helia and Moonstone), Locket of the Iron Solari is a great option. I advise this mythic item if you chose guardian as your keystone. On the other hand, if you take First Strike as your keystone and prefer to be more agressive and proactive in games, rushing Night Harvester as your mythic item, when you are versing squishy enemy teams , is a great option too. Its important to state that i only reccomend taking Night Harvester if you are experienced with karma, and can reliabily hit her skillshots, otherwise going any regular enchanter build will be better. Finally Radiant Virtue is also a potential build for karma, giving her much more survivability and helps her scale into the late game better, altough this item is extremely expensive, being sub-optimal when compared to any other enchanter mythic.

Boots

You should buy ionion boots of lucidity every single game! Unless the enemy team has 3 or more high cc champions, in which case you should opt for Mercury's threads, or the enemy team picked full ad or a team that consists of a lot of ad assasins (qiyana, talon, zed, kha'zix) you can buy plated steelcaps instead.

Reccomended Legendary Items

Echanter Items

By default karma is a champion with average ap ratios, she scales much better with ability haste. All the items listed above are great purchases on karma, Chemtech Dutrifier is great in most games, since most teams will have some sort of healing and it now offers heal and shield power. Redemption is amazing on karma for the stats and the active, can be built pretty much in any situation. Staff of Flowing Water is also a pretty safe item, providing your allies with bonus ap and ability haste. Ardent Censor is great if your team has 2 or more champions that synergise well with atack speed or on hit damage, such as hypercarry adcs (kog maw, vayne, jinx). Michaels Crucible can be bought in games when you have to cleanse a certain "death cc", helping keep your carries alive. The newly reworked Imperial madate, is a great option on karma if your team is lacking magic damage. Finally VIgilant Wardstone is a very underated item that can be purchased as a 3rd or 4th item most games since they usually dont go past 25/30 minutes.

Situational Items

These are situationally good items on karma, first Cosmic Drive can be bought due to its insanely high ability haste and kiting ability, Zhonyas Hourglass is an amazing option when facing heavy dive comps or champions that can very quickly kill you in a burst of damage. Horizon Focus and Void Staff are not good items on karma usually, although can be viable if you are building ap karma with Night Harvester and First Strike to further enhance her damage

Skill Order

You want to almost always be maxing your q anility first, then your e ability, and finally your w ability, obviously upping your mantra(r ability) whenever you can!
If you are winning lane very hard and want to opt into an Ap mythic maxing q into e is also a viable option.

Runes

Karma can use all 3 of these rune pages very well. Aery build is currently the best, you should always take it if you plan on building Moonstone as your mythic item, and most other games too. Arcane Commet is an option for very agressive laners that have some experience on karma and know how to exploit her early game very well. Honestly i dont like guardian at all, its once more a sit and afk kind of rune, you are not soraka, yuumi etc play agressive and take one of the other 2 options. The only situations i would advise guardian is if you are new to karma and never played her, or if you are not confortable into engage champions such as Leona, Rell, Nautillus, Blitz you get the point. But honestly learn after you learn karma, you should pretty much always take aery!

About me

Hello there! Im a EUW Karma Main and this is my Support Karma Guide. I have been playing her since i started playing the game in end of season 9, and managed to reach platinum in my first season. So far in season 12 i have managed to climb to diamond 3 for the first time! I hope you enjoyed this guide and find it helpfull in any way, im happy to answer any and all questions, on this page or you can also add me in game @Keisari Karma.