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Runes:
Spells:
Flash
Smite
Items
Ability Order
Eternal Hunger (PASSIVE)
Warwick Passive Ability
Threats & Synergies
Shaco
Shaco is the biggest threat for a warwick, he will invade you, kill you with his ignite and make you play from behind. Try not to pick warwick into shaco or at least be mindful of his invades. A good warwick player can, however, outsmart a shaco by simultaneously invading him, but you can also give this argument for any other champion. Your W is not that efficient in detecting him as you can't chase him down through your boxes.
Boots
1. If the enemy team has 5 AD champions, or 4 ad champions and at least 2 are autoattack reliant, get ninja tabis
2. If the enemy team has 3 AP champions or a lot of crowd control, get mercury's treads
If it gets to very late game, don't forget to upgrade your boots after you have finished all of your other items, generally go for mercury's treads for team fights.
For reference, TheDoggyHacker EUW.
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