Try to go with a healer like Soraka, so you can get heals and mana. At the begining just try to hit and run Champions with you're Tumble, then go for the kill when they are low. Always get a good farm you will be twice as good with it. You will get around 440 attack damage so it becomes really easy, Try ganking with your Final Hour{Uiltiment} so they are less likely to get away. Vayne can be good but bad when you vs someone who can out range you,so try to get a spot where you are ethier the only range or have the longer range. Well I hope who ever plays Vayne has a great time with her. ^_^