- With Heavenly Wave(HW), you can cause a really good damage in the enemy, just that. Try to don't spend Mantra with HW, the Mantra Bonus of HV it's not really good, so you need be conservative, and guard for Soul Shield, or Spirit Bond. Try to heal your allies when you're with low health, because the Mnatra Bonus of your HW gets stronger.
- Spirit Bond(SB) it's a good skill for chases and scapes. You don't need spend too much Mantra with SB, you will use Mantra just when you're on a gank, then you give movment speed to you, and let the enemy slow. You can also use in your ally, if you are in a couple kill, it's more beneficial. Try to do the enemies touch the bond, taking a good damage. A good trip for do it, it's using spirit bond on a minion, or something behind your target, then he takes a direct damage.
- I can say, Soul Shield(SS), it's the better skill of Karma. It can absorve a high damage, and cause a good damage. Like: If you or an ally have a Zilean's Time Bomb on your head, use SS, it can absorve almost all damage. To scape, use SS, it will protect you from long-range skills. To cause damage with SS, you need to activate Mantra. You can also use SS with Mantra Bonus on minions, to explode and take damage to enemies. In allied ganks, try to use SS with Mantra Bonus on allies near the enemy, to cause damage, and also make kills.

With Karma, you can take all lanes. In Top or Bot, try to support your ally with shield, and if you think you can, use HW with mantra bonus, to heal a bit your ally. Use SB, to take damage for your enemies and give movment speed for you, and your ally. Remember, it's more beneficial use SB in your ally, then you can cause damage in enemies.

In mid, try be conservative, don't use many skills on minions, don't stay healing yourself. To kill an enemy, try to take damages at times, and when you see that enemy's health it's not too high, use SS with Mantra Bonus, then use HW, to kill.

With this build, you will get A LOT of AP, and with your passive skill, you will be a monster. So, when you reach on your sixth item, change Doran's Ring for Zhoyna's Hourglass.