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Karthus
I heavily advise against getting Archangel's Staff as your first core. You don't have enough MP to make it an effective purchase yet, you only get around 90, MAX if you're lucky.
Try this
Sapphire Crystal 2x HP pots> Tear of the Goddess> Doran's Ring> Boots of Speed> Catalyst the Protector> (Finish Boots)> Deathcap/Rod of Ages
For a core.
also you may want to use text links instead of the massive icons in your guide. This part is a pain in the *** to describe.
yields Nidalee. Do this with any item, champion, or skill and it gives you the smaller icon.
Also with Masteries, the 4 points into the increased 5% mana isn't even worth it. If you have 1,000 mana, you get 50 mana as a bonus from having that mastery. It's more important to just take the Experience % mastery instead.