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LoL Best Middle Build Guides 2025

Build guides for Middle champions on MOBAFire. Find recommended items and runes by high ranked players to learn the best Middle builds. Create your own champion guide!



2025, Season 2 Guides // Patch 25.13
8.9
647
Votes
51
LoL Champion Anivia Build Guide
LoL Champion Anivia Build Guide

👉 🧊[ NEW SEASON 15 ] - Master's Guide to Midlane ANIVIA! S TIER PICK! 🧊 👈

Guide by RezoneVerified updated June 27, 2025
  • In-depth
8.9
277
Votes
25
LoL Champion Cho'Gath Build Guide
LoL Champion Cho'Gath Build Guide

[Season 14] Sakuritou Challenger Rank 1 Cho'Gath World Guide

Guide by Sakuritou updated June 26, 2025
  • In-depth
8.9
37
Votes
5
LoL Champion Ziggs Build Guide
LoL Champion Ziggs Build Guide

A Comprehensive Ziggs Primer

Guide by Laimaudeja updated June 25, 2025
  • In-depth
8.9
72
Votes
10
LoL Champion Nasus Build Guide
LoL Champion Nasus Build Guide

[25.13] Nasus Mid OTP - Simplest In-Depth Guide S2025

Guide by SurferKiller updated June 25, 2025
  • In-depth
8.7
24
Votes
4
LoL Champion Syndra Build Guide
LoL Champion Syndra Build Guide

15.13 My Potential is Limitless

Guide by Demonsedge90 updated June 25, 2025
  • In-depth
8.6
479
Votes
39
LoL Champion Orianna Build Guide
LoL Champion Orianna Build Guide

⚡ [SEASON 15 UPDATED!! ] Master Tier Midlane Orianna! THE BALLS HURT ⚡

Guide by RezoneVerified updated June 27, 2025
  • In-depth
8.3
240
Votes
21
LoL Champion Aurelion Sol Build Guide
LoL Champion Aurelion Sol Build Guide

[Patch 25.13] SEASON 15 Aurelion Sol Guide by Azzapp

Guide by Azzapp updated June 27, 2025
8.3
315
Votes
26
LoL Champion Hwei Build Guide
LoL Champion Hwei Build Guide

[Patch 25.13] Hwei Season 15 Guide By Azzapp [Mid/APC/Sup]

Guide by Azzapp updated June 27, 2025
7.7
25
Votes
9
LoL Champion Cho'Gath Build Guide
LoL Champion Cho'Gath Build Guide

[Season 14] Sakuritou Mathematically Correct Cho'Gath

Guide by Sakuritou updated June 26, 2025
  • In-depth
6.9
15
Votes
8
LoL Champion Yasuo Build Guide
LoL Champion Yasuo Build Guide

[Season 14] Sakuritou Challenger Yasuo Guide

Guide by Sakuritou updated June 26, 2025
6.7
17
Votes
10
LoL Champion Yone Build Guide
LoL Champion Yone Build Guide

[Season 14] Sakuritou Challenger Yone Guide

Guide by Sakuritou updated June 26, 2025
New Guide
LoL Champion Twisted Fate Build Guide
LoL Champion Twisted Fate Build Guide

Season 15, Ult. Haste Twisted Fate | Always Around

Guide by ChessScholar updated June 25, 2025
4.9
11
Votes
15
LoL Champion Katarina Build Guide
LoL Champion Katarina Build Guide

[Season 14] Sakuritou Challenger Katarina Guide

Guide by Sakuritou updated June 26, 2025
2025, Season 2 Guides // Patch 25.12
10
339
Votes
11
LoL Champion Kayle Build Guide
LoL Champion Kayle Build Guide

Rank 1 EUNE Top 8 EUW I Season 15 Kayle Guide by DesperateNasus Multi-season Challenger

Guide by Desperate Nasus updated June 24, 2025
  • In-depth
9.8
586
Votes
34
LoL Champion Cassiopeia Build Guide
LoL Champion Cassiopeia Build Guide

💀[NEW SEASON 15] CASSIOPEIA - The POISON Queen of Midlane ☠ 💀

Guide by RezoneVerified updated June 25, 2025
  • In-depth
9.8
579
Votes
87
LoL Champion Aatrox Build Guide
LoL Champion Aatrox Build Guide

[15.12] Aatrox Mega Guide 7m MP Master Top 100 worldwide

Guide by Veng Shotz updated June 20, 2025
  • In-depth
9.8
831
Votes
54
LoL Champion Twisted Fate Build Guide
LoL Champion Twisted Fate Build Guide

[25.12] Twisted Fate guide - Grandmaster, Halfhand 🥇

Guide by Halfhand updated June 20, 2025
  • In-depth
9.8
368
Votes
48
LoL Champion Sylas Build Guide
LoL Champion Sylas Build Guide

[25.12]✨ OTP Sylas MID Guide

Guide by angeLoon updated June 13, 2025
9.8
986
Votes
75
LoL Champion Irelia Build Guide
LoL Champion Irelia Build Guide

(25.11) Eriosun's Master Tier Complete Irelia Guide - Season 15 [UPDATED]

Guide by Eriosunx updated June 12, 2025
  • In-depth
9.7
175
Votes
14
LoL Champion Annie Build Guide
LoL Champion Annie Build Guide

[S15] Rank 1 Annie Complete Guide | By Coach xblademojo

Guide by xblademojo updated June 11, 2025
  • In-depth
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AatroxAhriAkaliAkshanAlistarAmbessaAmumuAniviaAnnieApheliosAsheAurelion SolAuroraAzirBardBel'VethBlitzcrankBrandBraumBriarCaitlynCamilleCassiopeiaCho'GathCorkiDariusDianaDr. MundoDravenEkkoEliseEvelynnEzrealFiddlesticksFioraFizzGalioGangplankGarenGnarGragasGravesGwenHecarimHeimerdingerHweiIllaoiIreliaIvernJannaJarvan IVJaxJayceJhinJinxK'SanteKai'SaKalistaKarmaKarthusKassadinKatarinaKayleKaynKennenKha'ZixKindredKledKog'MawLeBlancLee SinLeonaLilliaLissandraLucianLuluLuxMalphiteMalzaharMaokaiMaster YiMelMilioMiss FortuneMordekaiserMorganaNaafiriNamiNasusNautilusNeekoNidaleeNilahNocturneNunu & WillumpOlafOriannaOrnnPantheonPoppyPykeQiyanaQuinnRakanRammusRek'SaiRellRenata GlascRenektonRengarRivenRumbleRyzeSamiraSejuaniSennaSeraphineSettShacoShenShyvanaSingedSionSivirSkarnerSmolderSonaSorakaSwainSylasSyndraTahm KenchTaliyahTalonTaricTeemoThreshTristanaTrundleTryndamereTwisted FateTwitchUdyrUrgotVarusVayneVeigarVel'KozVexViViegoViktorVladimirVolibearWarwickWukongXayahXerathXin ZhaoYasuoYoneYorickYuumiZacZedZeriZiggsZileanZoeZyra
Teamfight Tactics Guide