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Nope my main is Ez and manamune is a waste of an item. Go straight AP and magic pen runes, u can finish off almost anny champ with ULT-Shift-flux combo, and yeah flash is the best cuz i average 0-2 deaths per game usually 0
and cooldown reduction is easy to get in items just get Nashors tooth and Ionian boots and ur almost at max CD reduction
I usually do not invest in Manamune, however some games it is needed to help farm. I have played a few pug games where we have nothing but assassins, which is a difficult combo, especially when it comes to farming minions. It is there if you need it.
That said, true it does not directly affect your spells, aside from mana.
Nashor's Tooth is completely worthless on an AP Ezi, not sure why you'd every pick one up, especially for the price.
and cooldown reduction is easy to get in items just get Nashors tooth and Ionian boots and ur almost at max CD reduction